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Org Lett. 2005 Oct 27;7(22):4927-30.

An efficient and versatile solid-phase synthesis of 5'- and 3'-conjugated oligonucleotides.

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1
Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli Federico II, Complesso Universitario di Monte S. Angelo, Italy.

Abstract

[reaction: see text] An easy and efficient solid-phase strategy to obtain 5'- and 3'-oligonucleotide conjugates in highly pure form has been developed. Ad hoc derivatized solid supports, to which the first nucleoside unit can be attached through a phosphate linkage, have been exploited both in a pre- and post-DNA assembly conjugation approach. A number of 5'- or 3'- oligonucleotide conjugates, incorporating a variety of labels covalently linked through a phosphodiester or a phosphoramidate bond, have been synthesized and characterized.

PMID:
16235924
DOI:
10.1021/ol051811g
[Indexed for MEDLINE]
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