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IEEE Trans Biomed Eng. 2005 Oct;52(10):1654-61.

Nonlinear conductance-volume relationship for murine conductance catheter measurement system.

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Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX 78712, USA.


The conductance catheter system is a tool to determine instantaneous left ventricular volume in vivo by converting measured conductance to volume. The currently adopted conductance-to-volume conversion equation was proposed by Baan, and the accuracy of this equation is limited by the assumption of a linear conductance-volume relationship. The electric field generated by a conductance catheter is nonuniform, which results in a nonlinear relationship between conductance and volume. This paper investigates this nonlinear relationship and proposes a new nonlinear conductance-to-volume conversion equation. The proposed nonlinear equation uses a single empirically determined calibration coefficient, derived from independently measured stroke volume. In vitro experiments and numerical model simulations were performed to verify and validate the proposed equation.

[Indexed for MEDLINE]

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