Format

Send to

Choose Destination
Cell. 1992 Jul 10;70(1):163-76.

The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos.

Author information

1
Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.

Abstract

During C. elegans embryogenesis an 8-cell stage blastomere, called MS, undergoes a reproducible cleavage pattern, producing pharyngeal cells, body wall muscles, and cell deaths. We show here that maternal-effect mutations in the pie-1 and mex-1 genes cause additional 8-cell stage blastomeres to adopt a fate very similar to that of the wild-type MS blastomere. In pie-1 mutants one additional posterior blastomere adopts an MS-like fate, and in mex-1 mutants four additional anterior blastomeres adopt an MS-like fate. We propose that maternally provided pie-1(+) and mex-1(+) gene products may function in the early embryo to localize or regulate factors that determine the fate of the MS blastomere.

PMID:
1623520
DOI:
10.1016/0092-8674(92)90542-k
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center