Send to

Choose Destination
Br J Cancer. 2005 Oct 31;93(9):1053-6.

Meta-analysis of cancer incidence in children born after assisted reproductive technologies.

Author information

Fondazione Policlinico IRCCS-Molecular and Genetic Epidemiology Unit, via Pace 9, Milano 20122, Italy.


A meta-analysis was performed on 11 cohort studies of Assisted Reproductive Technologies (ART) and subsequent childhood cancer, published up to February 2005, which reported comparable, nonoverlapping data, and then restricted to eight studies which presented a similar research design. The overall Standardised Incidence Ratio was 1.33 (95% CI 0.62-2.85), and 0.77 (95% CI 0.41-1.42) when the analysis was restricted to eight studies. No evidence of publication bias was observed for the overall analysis. The data are consistent with a lack of increase in risk of childhood cancer, though the amount of data on ART and cancer is still limited; larger multicentric studies as well as a pooled analysis on the available data are warranted.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central Icon for PubMed Health
Loading ...
Support Center