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Nat Neurosci. 2005 Nov;8(11):1500-2. Epub 2005 Oct 23.

COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome.

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1
Center for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, 401 Quarry Road, Stanford, California 94305-5795, USA.

Abstract

Although schizophrenia is strongly hereditary, there are limited data regarding biological risk factors and pathophysiological processes. In this longitudinal study of adolescents with 22q11.2 deletion syndrome, we identified the catechol-O-methyltransferase low-activity allele (COMT(L)) as a risk factor for decline in prefrontal cortical volume and cognition, as well as for the consequent development of psychotic symptoms during adolescence. The 22q11.2 deletion syndrome is a promising model for identifying biomarkers related to the development of schizophrenia.

PMID:
16234808
DOI:
10.1038/nn1572
[Indexed for MEDLINE]
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