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Rheumatology (Oxford). 2006 Feb;45(2):192-5. Epub 2005 Oct 18.

Diagnostic value of blind synovial biopsy in clinical practice.

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1
Erasmus MC, Department of Rheumatology, Z-712, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

Abstract

OBJECTIVE:

To assess the diagnostic value of blindly performed synovial biopsies in carefully selected patients with unclassified arthritis.

METHODS:

Synovial tissue was obtained blindly under local anaesthesia. The Arthroforce III take-apart 3.5 mm needle and 1.5 mm grasping forceps were used for this purpose.

RESULTS:

Four patients with unclassified arthritis could be diagnosed properly based upon examination of synovial tissue of the knee obtained by an easy-to-perform blind biopsy. The arthritis of the four patients was diagnosed as being part of Erdheim-Chester disease, sarcoidosis, multicentric reticulohistiocytosis and arthritis caused by foreign-body material, respectively.

CONCLUSIONS:

Analysis of synovial tissue obtained during a blind biopsy procedure has diagnostic potential in carefully selected patients with unclassified arthritis. The common denominator in all the cases presented was a differential diagnosis consisting of a rheumatological disease with characteristic histological features.

PMID:
16234280
DOI:
10.1093/rheumatology/kei117
[Indexed for MEDLINE]
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