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Curr Opin Neurol Neurosurg. 1992 Apr;5(2):195-202.

Immunology of multiple sclerosis.

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Department of Neurology, Karolinska Institutet, Huddinge Hospital, Stockholm, Sweden.


Recent advances in the understanding of the immunology of multiple sclerosis (MS) are discussed. In the central nervous system (CNS) major histocompatibility complex (MHC) class I and II antigens, and lymphocyte adhesion molecules are expressed. Furthermore, there are cells present which produce important effector molecules such as interferon (IFN)-gamma and tumor necrosis factor (TNF). A role for myelin antigen-specific autoimmunity is supported, but not proven, by the presence of a marked quantitative increase of T and B cells with such specificities, enriched to the CNS. Several myelin antigens, as well as a multitude of peptide parts of these, are apparently recognized. It will be of interest to study the functional abilities of these cells and how they are regulated.

[Indexed for MEDLINE]

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