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Semin Cell Biol. 1992 Jun;3(3):169-78.

Cell adhesion in invasion and metastasis.

Author information

1
University of Essen Medical School, Germany.

Abstract

Metastatic cells exhibit considerable flexibility in their adhesive interactions with other cells or components of the extracellular matrix. This review will describe the involvement of specific adhesion receptors, extracellular matrix molecules and cell dissociating cytokines in the metastatic cascade. We will particularly focus on disturbance of intercellular adhesion as a prerequisite for the release of invasive cells from carcinomas. We suggest that cell dissociation in these tumours is accomplished by loss of function or expression of the epithelial cell adhesion molecule E-cadherin, and through the activity of cell motility factors such as the scatter factor.

PMID:
1623206
DOI:
10.1016/s1043-4682(10)80013-3
[Indexed for MEDLINE]

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