Format

Send to

Choose Destination
Nat Rev Mol Cell Biol. 2005 Sep;6(9):743-8. doi: 10.1038/nrm1712.

Two-way traffic: centrosomes and the cell cycle.

Author information

1
Department of Cell Biology, University of Massachusetts Medical School, Worcester 01605, USA. greenfield.sluder@umassmed.edu

Abstract

The well recognized activities of the mammalian centrosome--microtubule nucleation, duplication, and organization of the primary cilium--are under the control of the cell cycle. However, the centrosome is more than just a follower of the cell cycle; it can also be essential for the cell to transit G1 and enter S phase. How the centrosome influences G1 progression is a mystery.

PMID:
16231423
DOI:
10.1038/nrm1712
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center