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Int J Eat Disord. 2005 Dec;38(4):295-300.

Topiramate treatment in bulimia nervosa patients: a randomized, double-blind, placebo-controlled trial.

Author information

1
Clinic for Psychosomatic Medicine, Inntalklinik, Simbach am Inn, Germany. m.nickel@inntalklinik.de

Abstract

OBJECTIVE:

The aim of the current study was to test the influence of topiramate on behavior, body weight, and health-related quality of life (HRQOL) in bulimic patients.

METHOD:

Thirty patients with bulimia nervosa were treated with topiramate in a 10-week randomized, double-blind, placebo-controlled study. The subjects were randomly assigned to receive topiramate (topiramate group [TG]; n = 30) or a placebo (control group [CG]; n = 30). Primary outcome measures were changes in the frequency of binging/purging, in body weight, and on the SF-36 Health Survey (SF-36) scales.

RESULTS:

In comparison to the CG group (according to the intent-to-treat principle), significant changes in the frequency of binging/purging (a > 50% reduction: TG, n = 11 [36.7%]; CG, n = 1 [3.3%]; p < .001), body weight (difference in weight loss between the two groups: 3.8 kg, 95% confidence interval [CI] = -5.4 to -2.1; p < .001), and SF-36 (all ps < .001) could be seen. All patients tolerated topiramate well.

CONCLUSION:

Topiramate appears to safe and effective in influencing the frequency of binging/purging, body weight, and HRQOL in bulimic patients.

PMID:
16231337
DOI:
10.1002/eat.20202
[Indexed for MEDLINE]

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