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Nat Struct Mol Biol. 2005 Nov;12(11):1017-8.

A minimal domain responsible for Munc13 activity.

Author information

1
Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

Abstract

Munc13 proteins are essential in neurotransmitter release, controlling the priming of synaptic vesicles to a release-ready state. The sequences responsible for this priming activity are unknown. Here we identify a large alpha-helical domain of mammalian Munc13-1 that is autonomously folded and is sufficient to rescue the total arrest in neurotransmitter release observed in hippocampal neurons lacking Munc13s.

PMID:
16228007
DOI:
10.1038/nsmb1001
[Indexed for MEDLINE]

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