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Immunity. 2005 Oct;23(4):344-6.

Macrophage polarization comes of age.

Author information

1
Istituto Clinico Humanitas, and Institute of General Pathology, University of Milan, Milan, Italy.

Abstract

Functional polarization of macrophages into M1 or M2 cells is an operationally useful, simplified conceptual framework describing the plasticity of mononuclear phagocytes. Genetic approaches have begun to shed new light on mechanisms underlying macrophage polarization and on the actual in vivo significance of polarized M2 cells ( [this issue of Immunity]).

PMID:
16226499
DOI:
10.1016/j.immuni.2005.10.001
[Indexed for MEDLINE]
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