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FEBS Lett. 2005 Oct 24;579(25):5798-5802.

The intracellular domain of Notch ligand Delta1 induces cell growth arrest.

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1
Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, 04074, USA.

Abstract

Notch signaling involves proteolytic cleavage of the transmembrane Notch receptor after binding to its transmembrane ligands, Delta or Jagged; and the resultant soluble intracellular domain of Notch stimulates a cascade of transcriptional events. The Delta1 ligand also undergoes proteolytic cleavage upon Notch binding, resulting in the production of a free intracellular domain. We demonstrate that the expression of the intracellular domain of Delta1 results in a non-proliferating senescent-like cell phenotype which is dependent on the expression of the cell cycle inhibitor, p21, and is abolished by co-expression of constitutively active Notch1. These data suggest a new intracellular role for Delta1.

PMID:
16225865
DOI:
10.1016/j.febslet.2005.09.042
[Indexed for MEDLINE]
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