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Arthritis Rheum. 1992 Jul;35(7):761-4.

The effect of food on the absorption of methotrexate sodium tablets in healthy volunteers.

Author information

1
Medical Development Section, Lederle Laboratories, Pearl River, New York 10965.

Abstract

OBJECTIVE:

To examine the effect of food on the absorption and bioavailability of low-dose orally administered methotrexate sodium tablets.

METHODS:

In this randomized, 2-way crossover study, a 7.5-mg dose of methotrexate (three 2.5-mg tablets) was administered to 12 healthy male volunteers after an overnight fast or within 10 minutes of consuming a high fat-content breakfast. Serum methotrexate concentrations over the next 24 hours were used to determine the area under the concentration-time curve (AUC), the maximum concentration, the time to maximum concentration (tmax), and the serum half-life for each phase.

RESULTS:

Food delayed the tmax by approximately 30 minutes, but the extent of absorption, as measured by the AUC, for both phases was similar.

CONCLUSION:

These results demonstrate that the bioavailability of low-dose orally administered methotrexate sodium tablets is not influenced by food.

PMID:
1622413
DOI:
10.1002/art.1780350708
[Indexed for MEDLINE]

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