Format

Send to

Choose Destination
Science. 2005 Oct 14;310(5746):321-4.

A fine-scale map of recombination rates and hotspots across the human genome.

Author information

1
Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.

Abstract

Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest a two-stage model for recombination in which hotspots are stochastic features, within a framework in which large-scale rates are constrained.

Comment in

PMID:
16224025
DOI:
10.1126/science.1117196
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center