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Trends Genet. 2005 Dec;21(12):664-72. Epub 2005 Oct 10.

Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum.

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1
Department of Molecular Genetics (VIB 8), Flanders Interuniversity Institute for Biotechnology, Neurodegenerative Brain Diseases Group, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B-2610 Antwerpen, Belgium.

Abstract

In contrast to the common and genetically complex senile form of Alzheimer's disease (AD), the molecular genetic dissection of inherited presenile dementias has given important mechanistic insights into the pathogenesis of degenerative brain disease. Here, we focus on recent genotype-phenotype correlative studies in presenile AD and the frontotemporal dementia (FTD) complex of disorders. Together, these studies suggest that AD and FTD are linked in a genetic spectrum of presenile degenerative brain disorders in which tau appears to be the central player.

PMID:
16221505
DOI:
10.1016/j.tig.2005.09.005
[Indexed for MEDLINE]
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