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Trends Mol Med. 2005 Nov;11(11):512-8. Epub 2005 Oct 10.

BMP7 signaling in renal development and disease.

Author information

1
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

Fibrosis, and in particular tubulointerstitial fibrosis, is a common feature of almost all chronic renal diseases. Over the past several years, significant progress has been made in defining the underlying mechanisms of tubulointerstitial fibrosis. In a variety of mouse models, expression of transforming growth factor-beta is a primary causative factor which leads to increased numbers of myofibroblasts, collagen deposition and loss of tubular epithelia. More recently, another member of the transforming growth factor-beta superfamily, BMP7, was shown to counteract transforming growth factor-beta-mediated fibrosis. The activities of these secreted factors are regulated, in part, by extracellular ligand binding proteins which can enhance or suppress receptor ligand interactions.

PMID:
16216558
DOI:
10.1016/j.molmed.2005.09.007
[Indexed for MEDLINE]

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