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Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10.

Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.

Author information

1
Abbott Bioresearch Center, 100 Research Drive, Worcester, MA 01605-5314, USA.

Abstract

We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.

PMID:
16216497
DOI:
10.1016/j.bmcl.2005.09.039
[Indexed for MEDLINE]

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