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Bioorg Med Chem Lett. 2006 Jan 1;16(1):176-80. Epub 2005 Oct 10.

Pulvinones as bacterial cell wall biosynthesis inhibitors.

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1
Medicinal Chemistry, Chemical and Screening Sciences, Wyeth Research, Princeton, NJ 08543, USA. antanes@wyeth.com

Abstract

Pulvinones were synthesized (>180) in arrays and evaluated as inhibitors of early stage cell wall biosynthesis enzymes MurA-MurD. Several pulvinones inhibited Mur enzymes with IC(50)'s in the 1-10 microg/mL range and demonstrated antibacterial activity against Gram-positive bacteria including methicillin-resistant Staphyloccus aureus, vancomycin-resistant Enterococcus faecalis, and penicillin-resistant Streptococcus pneumoniae.

PMID:
16216496
DOI:
10.1016/j.bmcl.2005.09.021
[Indexed for MEDLINE]
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