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FEMS Microbiol Lett. 2005 Nov 1;252(1):1-10. Epub 2005 Sep 8.

Type III secretion: the bacteria-eukaryotic cell express.

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1
Biozentrum der Universit├Ąt Basel, Biozentrum, Klingelbergstrasse, 50-70 CH4051 Basel, Switzerland.

Abstract

Type III secretion (T3S) is an export pathway used by Gram-negative pathogenic bacteria to inject bacterial proteins into the cytosol of eukaryotic host cells. This pathway is characterized by (i) a secretion nanomachine related to the bacterial flagellum, but usually topped by a stiff needle-like structure; (ii) the assembly in the eukaryotic cell membrane of a translocation pore formed by T3S substrates; (iii) a non-cleavable N-terminal secretion signal; (iv) T3S chaperones, assisting the secretion of some substrates; (v) a control mechanism ensuring protein delivery at the right place and time. Here, we review these different aspects focusing in open questions that promise exciting findings in the near future.

PMID:
16216444
DOI:
10.1016/j.femsle.2005.08.036
[Indexed for MEDLINE]
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