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J Magn Reson Imaging. 2005 Nov;22(5):605-13.

Multi-contrast delayed enhancement provides improved contrast between myocardial infarction and blood pool.

Author information

1
Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland 20892-1061, USA.

Abstract

PURPOSE:

To develop and test a delayed-enhancement imaging method for improving the contrast between myocardial infarction (MI) and blood pool.

MATERIALS AND METHODS:

The T(2) of blood is significantly longer than that of acute or chronic MI. The proposed multi-contrast delayed-enhancement (MCODE) imaging method produces a series of images with both T(1) and T(2) weightings, which provides both excellent contrast between normal and infarcted myocardium, and between blood and MI.

RESULTS:

The subendocardial border between MI and blood pool was easily discriminated in the T(2)-weighted image. The measured MI-to-blood contrast-to-noise ratio (CNR) was better in the T(2)-weighted image than in the T(1)-weighted image (22.5+/-8.7 vs. 2.9+/-3.1, mean+/-SD, N=11, P<0.001, for True FISP, and 19.4+/-10.8 vs. 3.9+/-2.3, N=11, P<0.001, for Turbo FLASH).

CONCLUSION:

The MCODE method provides a significant improvement in the ability to easily discriminate subendocardial MI by providing a T(2)-weighted image with high contrast between blood and MI. MCODE should improve both the detection and accurate sizing of MI.

PMID:
16215969
PMCID:
PMC2396274
DOI:
10.1002/jmri.20426
[Indexed for MEDLINE]
Free PMC Article
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