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Curr Opin Genet Dev. 2005 Dec;15(6):660-5. Epub 2005 Oct 7.

Sex chromosomes and sex determination in reptiles.

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  • 1SAIC Frederick, National Cancer Institute, Core Genotyping Facility, 8717 Grovemont Circle, Gaithersburg, MD 20877, USA.


Reptiles occupy a crucial position with respect to vertebrate phylogeny, having roamed the earth for more than 300 million years and given rise to both birds and mammals. To date, this group has been largely ignored by contemporary genomics technologies, although the green anole lizard was recently recommended for whole genome sequencing. Future experiments using flow-sorted chromosome libraries and high-throughout genomic sequencing will help to discover important findings regarding sex chromosome evolution, early events in sex determination, and dosage compensation. This information should contribute extensively toward a general understanding of the genetic control of development in amniotes.

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