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Fertil Steril. 2005 Oct;84(4):919-24.

Effect of chronic alcoholism on male fertility hormones and semen quality.

Author information

1
The Tamil Nadu Dr. M.G.R. Medical University, Chennai, India. muthusamikr@yahoo.co.in

Abstract

OBJECTIVE:

To evaluate the effects of chronic alcoholism on the male fertility hormones and quality of semen.

DESIGN:

Non-probability purposive clinical study.

SETTING:

Addiction treatment center and an academic research environment.

PATIENT(S):

Sixty-six alcoholics free from smoking and drug abuse who consumed a minimum of 180 mL of alcohol per day (brandy and whisky, both 40%-50% alcohol content) for a minimum of 5 days per week for > or =1 year were included. Thirty nonsmoking nonalcoholics were selected as controls.

INTERVENTION(S):

Before starting the addiction treatment for alcoholics, venous blood and semen samples were collected.

MAIN OUTCOME MEASURE(S):

Complete blood counts, biochemical parameters, levels of the male fertility hormones FSH, LH, T, PRL, P, and E2 in blood, and semen parameters.

RESULT(S):

In alcoholics, FSH, LH, and E2 levels were significantly increased, and T and P levels were significantly decreased. No significant change was noted in PRL levels. Semen volume, sperm count, motility, and number of morphologically normal sperm were significantly decreased.

CONCLUSION(S):

Chronic alcohol consumption has a detrimental effect on male reproductive hormones and on semen quality.

[Indexed for MEDLINE]

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