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Bioorg Med Chem. 2006 Feb 15;14(4):1029-38. Epub 2005 Oct 5.

Synthesis and properties of 2'-O,4'-C-methyleneoxymethylene bridged nucleic acid.

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1
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.

Abstract

A novel bridged nucleic acid (BNA) analogue, 2'-O,4'-C-methyleneoxymethylene bridged nucleic acid (2',4'-BNA(COC)), was synthesized and incorporated into oligonucleotides. The 2',4'-BNA(COC) modified oligonucleotides showed high binding affinity with an RNA complement and significant enzymatic stability against snake venom phosphodiesterase.

PMID:
16213732
DOI:
10.1016/j.bmc.2005.09.020
[Indexed for MEDLINE]
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