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Vaccine. 2006 Feb 27;24(9):1413-20. Epub 2005 Sep 22.

Interleukin-12 induces a Th1-like response to Burkholderia mallei and limited protection in BALB/c mice.

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Bacteriology Division, United States Army Research Institute of Infectious Diseases, Frederick, MD 21702, USA.


We evaluated the effect of interleukin (IL)-12 on the immune response to Burkholderia mallei in BALB/c mice. Mice were vaccinated with non-viable B. mallei cells with or without IL-12. There was a seven- to nine-fold increase in IgG2a levels, and a significant increase in the proliferative response and interferon (IFN)-gamma production by splenocytes from mice that received B. mallei and IL-12. We saw an increase in survivors in the groups of mice that received B. mallei and IL-12 when challenged, compared to mice that received only B. mallei or IL-12. The results suggest that IL-12 can enhance the Th1-like immune response to B. mallei and mediate limited protection from a lethal challenge.

[Indexed for MEDLINE]

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