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Life Sci. 2005 Dec 22;78(5):527-31. Epub 2005 Oct 6.

Psychopharmacology of the hallucinogenic sage Salvia divinorum.

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Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, S327 PHAR, MNPC, 115 S. Grand Ave., Iowa City, IW 52242, USA.


At present, the Mexican mint Salvia divinorum is an unregulated hallucinogen. This has resulted in various on-line botanical companies advertising and selling S. divinorum as a legal alternative to other regulated plant hallucinogens. It is predictable that its misuse will increase rapidly. The active ingredient in S. divinorum is the neoclerodane diterpene, salvinorin A (1a), which has been shown to be a kappa agonist both in vitro and in vivo. This review will cover the current state of research into the psychopharmacology of S. divinorum.

[Indexed for MEDLINE]

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