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Life Sci. 2005 Dec 22;78(5):527-31. Epub 2005 Oct 6.

Psychopharmacology of the hallucinogenic sage Salvia divinorum.

Author information

1
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, S327 PHAR, MNPC, 115 S. Grand Ave., Iowa City, IW 52242, USA. thomas-prisinzano@uiowa.edu

Abstract

At present, the Mexican mint Salvia divinorum is an unregulated hallucinogen. This has resulted in various on-line botanical companies advertising and selling S. divinorum as a legal alternative to other regulated plant hallucinogens. It is predictable that its misuse will increase rapidly. The active ingredient in S. divinorum is the neoclerodane diterpene, salvinorin A (1a), which has been shown to be a kappa agonist both in vitro and in vivo. This review will cover the current state of research into the psychopharmacology of S. divinorum.

PMID:
16213533
DOI:
10.1016/j.lfs.2005.09.008
[Indexed for MEDLINE]

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