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J Comp Pathol. 2005 Nov;133(4):261-6. Epub 2005 Oct 6.

Experimental Trypanosoma evansi infection in the goat. I. Clinical signs and clinical pathology.

Author information

1
College of Veterinary Medicine, Central Mindanao University, Musuan 8710, Bukidnon, Philippines.

Abstract

A strain of Trypanosoma evansi isolated from an equine case of surra in Mindanao, Philippines was used to infect intravenously two groups (A and B) of five male goats aged 8-10 months. Animals of groups A and B received 5000 and 50 000 trypanosomes, respectively, and five further animals (group C) served as uninfected controls. Four of the 10 infected goats died 8-78 days after inoculation. Group C goats gained weight (mean 22.8 g/day) while infected goats in groups A and B lost weight (means of 21.4 and 45.0 g/day, respectively). Parasitaemia fluctuated regularly between peaks and troughs, with repeated periods of about 6 days during which no trypanosomes were detected in the blood. Clinical signs and clinico-pathological changes in infected goats were not pathognomonic in the absence of parasites in the blood, and leucocytosis was not a reliable indicator of infection. It was concluded that in endemic areas fluctuating fever, progressive emaciation, anaemia, coughing, testicular enlargement and diarrhoea are suggestive of surra; confirmation, however, may necessitate examination of blood every few days for trypanosomes, and possibly other diagnostic tests.

PMID:
16213515
DOI:
10.1016/j.jcpa.2005.06.001
[Indexed for MEDLINE]

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