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Cell. 2005 Oct 7;123(1):13-24.

Right place, right time, and only once: replication initiation in metazoans.

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1
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

Abstract

DNA replication is tightly regulated at the initiation step by both the cell cycle machinery and checkpoint pathways. Here, we discuss recent advances in understanding how replication is initiated in metazoans at the correct chromosome positions, at the appropriate time, and only once per cell cycle.

PMID:
16213209
DOI:
10.1016/j.cell.2005.09.019
[Indexed for MEDLINE]
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