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Cell. 2005 Oct 7;123(1):9-12.

The blood-brain barrier--lessons from moody flies.

Author information

1
Department of Neurobiology, Stanford University School of Medicine, CA 94305, USA. rdaneman@stanford.edu

Abstract

Despite the importance of the blood-brain barrier (BBB), little is known about the molecular mechanisms that control its integrity. The identification of moody, a gene required for the formation and maintenance of the Drosophila BBB, provides new insight into how paracellular junctions are formed at the barrier. Meanwhile, moody also has been identified in a screen for fly mutants with altered sensitivity to cocaine, remarkably implicating the BBB in the physiological response to narcotics.

PMID:
16213208
DOI:
10.1016/j.cell.2005.09.017
[Indexed for MEDLINE]
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