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Biochim Biophys Acta. 2005 Nov 30;1726(3):326-7. Epub 2005 Sep 22.

Expression of tcaA and mprF and glycopeptide resistance in clinical glycopeptide-intermediate Staphylococcus aureus (GISA) and heteroGISA strains.

Author information

1
Department of Pathology and Microbiology, Bristol Centre for Antimicrobial Research and Evaluation, Medical Sciences, University of Bristol, and North Bristol Healthcare Trust, Southmead Hospital, Bristol, UK. mandy.wootton@bristol.ac.uk

Abstract

Two genes recently associated with glycopeptide intermediate resistance in Staphylococcus aureus (GISA) are mprF and tcaA, with inactivation causing shifts in vancomycin resistance. This study reveals that expression levels of both genes are similar in groups of clinical GISA, heteroGISA and glycopeptide susceptible strains, suggesting no association with clinical isolates.

PMID:
16213099
DOI:
10.1016/j.bbagen.2005.09.002
[Indexed for MEDLINE]

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