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J Struct Funct Genomics. 2005;6(2-3):71-9.

Protein production and crystallization at the joint center for structural genomics.

Author information

1
Joint Center for Structural Genomics, Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, 92121 CA, USA. slesley@gnf.org

Abstract

By definition, structural genomics centers must be able to address a large number of diverse protein targets. The methods developed should permit parallel and cost-effective processing while allowing for the diverse nature of proteins. Our approach to this problem is a multi-tiered effort where targets are characterized and categorized by behavior and processed in parallel by appropriate methods. The Joint Center for Structural Genomics (JCSG) has applied this tactic to create a fully integrated and scaleable structure determination pipeline. Highlights of the development of the current pipeline for protein production and crystallization are presented here.

PMID:
16211502
DOI:
10.1007/s10969-005-2897-2
[Indexed for MEDLINE]

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