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Eur J Cancer. 2005 Nov;41(16):2577-86. Epub 2005 Oct 4.

Transcription factors and drug resistance.

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Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Fukuoka 807-8555, Japan.


Intrinsic or acquired resistance to anticancer agents is a major obstacle to the success of chemotherapy. Anticancer agents are known to modulate signal transduction pathways and alter expression of genes that play an important role in drug resistance. Emerging evidence suggests that the complexity of genomic response against anticancer agents arise from elaborate gene expression by multiple transcription factors. Here, we briefly describe the development of solid tumours and the appearance of drug-resistant cells. We also review what is known of the transcription factors that are involved in resistance to drugs, particularly cisplatin.

[Indexed for MEDLINE]

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