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Expert Rev Proteomics. 2005 Oct;2(5):719-29.

Histone structure and nucleosome stability.

Author information

1
Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. marino@ncbi.nlm.nih.gov

Abstract

Histone proteins play essential structural and functional roles in the transition between active and inactive chromatin states. Although histones have a high degree of conservation due to constraints to maintain the overall structure of the nucleosomal octameric core, variants have evolved to assume diverse roles in gene regulation and epigenetic silencing. Histone variants, post-translational modifications and interactions with chromatin remodeling complexes influence DNA replication, transcription, repair and recombination. The authors review recent findings on the structure of chromatin that confirm previous interparticle interactions observed in crystal structures.

PMID:
16209651
PMCID:
PMC1831843
DOI:
10.1586/14789450.2.5.719
[Indexed for MEDLINE]
Free PMC Article

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