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Minerva Endocrinol. 2005 Sep;30(3):193-7.

[Relationship between insulin secretion, and thyroid and ovary function in patients suffering from polycystic ovary].

[Article in Italian]

Author information

1
Dipartimento di Fisiopatologia Clinica, Policlinico Umberto I, Università degli Studi di Roma, Roma.

Abstract

AIM:

The present paper investigates the relationship between polycystic ovary syndrome, hypothyroidism and insulin-resistance and how, by submitting patients to a specific therapy for any one of the three pathologies, we also obtain an improvement in the other associated pathologies.

METHODS:

We selected 45 patients aged between 16 and 25 with problems of polycystic ovary syndrome, hypothyroidism and insulin-resistance and divided them into 3 groups. The 15 Group A patients followed a dietetic therapy. The 15 patients of Group B received hormonal therapy. The 15 Group C patients received replacement therapy with laevo-thyroxine. All patients had their thyroid and ovary function checked every six months and a glycoinsulinaemic curve was plotted after glucose loading.

RESULTS:

A reduction in TSH levels and an increase in the values of circulating thyroid hormones was observed in all patients. The ovary situation underwent both a hormonal and symptomatological improvement with diminution in LH and testosterone levels and an increase in progesterone. The glucose-insulin picture of our patients progressively improved in all 3 groups studied.

CONCLUSIONS:

The data obtained in our study enable us to support the close connection between ovary function, thyroid function and insulin-resistance. In all patients, in fact, albeit at different times, an improvement was obtained in all 3 pathologies.

PMID:
16208308
[Indexed for MEDLINE]

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