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Schmerz. 2006 Aug;20(4):285-8, 290-2.

[Effectiveness and time to onset of pregabalin in patients with neuropathic pain].

[Article in German]

Author information

1
Klinik für Anästhesiologie, Universitätsklinikum Düsseldorf. Freynhagen@med.uni-duesseldorf.de

Abstract

BACKGROUND:

The data from a previously published 12-week randomised, double-blind, placebo-controlled multicentre study on the efficacy and safety of pregabalin were analyzed for time to onset of analgesic action with neuropathic pain.

PATIENTS AND METHODS:

A total of 338 patients with postherpetic neuralgia or painful diabetic peripheral neuropathy were treated with flexible or fixed regimens of pregabalin at daily doses of up to 600 mg/day (n=141 and 132, respectively) or placebo (n=65).

RESULTS:

Under fixed dose treatment, a decrease of one full point on the 11-point numerical rating pain scale was reached on day 1, two full points on day 13, and three full points on day 23 (under flexible dose pregabalin: on days 6, 17 and 30). In both treatment arms, pain reduction was statistically significant (P=0.001, P=0.002 vs placebo, respectively).

CONCLUSION:

In patients with chronic neuropathic pain, the analgesic effect of both pregabalin treatment regimens was high and associated with a rapid time to onset.

PMID:
16205904
DOI:
10.1007/s00482-005-0449-0
[Indexed for MEDLINE]
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