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Cancer Res. 2005 Oct 1;65(19):8575-8.

The transcription factor Pokemon: a new key player in cancer pathogenesis.

Author information

1
Cancer Biology and Genetics Program, Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Abstract

Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics.

PMID:
16204018
DOI:
10.1158/0008-5472.CAN-05-1055
[Indexed for MEDLINE]
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