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Bioorg Med Chem Lett. 2005 Dec 1;15(23):5114-9. Epub 2005 Oct 3.

Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints.

Author information

1
Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA. ghchu@adolor.com

Abstract

Two novel chemical classes of kappa opioid receptor agonists, chroman-2-carboxamide derivatives and 2,3-dihydrobenzofuran-2-carboxamide derivatives, were synthesized. These agents exhibited high and selective affinity for the kappa opioid receptor.

PMID:
16203140
DOI:
10.1016/j.bmcl.2005.08.094
[Indexed for MEDLINE]

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