Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Obstet Gynecol. 2005 Oct;193(4):1472-7.

Association between fetal interleukin-1 receptor antagonist gene polymorphism and unexplained fetal death.

Author information

1
Department of Obstetrics and Gynecology, Institute of Pathology, Lausanne, Switzerland. Stefan.Gerber@chuv.hospvd.ch

Abstract

OBJECTIVE:

In spite of extensive clinical examinations or autopsies, as many as 15% to 40% of stillbirths remain unexplained. A systemic fetal inflammatory response is an independent risk factor for severe neonatal morbidity, mediated by proinflammatory cytokines. As a major anti-inflammatory cytokine, interleukin-1 receptor antagonist (IL-1ra) plays a crucial role modulating the proinflammatory response. The gene coding for IL-1ra (IL1RN) is polymorphic. We hypothesized that fetal possession of a specific allele, IL-1RN*2, associated with increased proinflammatory responses, may increase susceptibility to intrauterine fetal death.

STUDY DESIGN:

Fetal kidney cells were obtained from paraffin blocks of 27 unexplained stillbirths. DNA was isolated and tested for IL-1RN genotypes by polymerase chain reaction. As a control group, DNA from 302 live births was also tested.

RESULTS:

There was an enhanced rate of IL-1RN*2 homozygocity, 41%, among unexplained stillbirths compared with the control group, 8.6% (P < .001). Histologic analysis of fetal tissues demonstrated a predominant proinflammatory response in IL-1RN*2 homozygote fetuses. Extensive screening (microbiology, maternal serology, placenta histology) did not identify any specific trigger agent.

CONCLUSION:

There is an association between unexplained stillbirth and fetal homozygous IL1RN*2 carriage.

PMID:
16202742
DOI:
10.1016/j.ajog.2005.02.112
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center