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J Clin Invest. 2005 Oct;115(10):2665-72.

Caspases: pharmacological manipulation of cell death.

Author information

  • 1Division of Immunogenetics, Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany.

Abstract

Caspases, a family of cysteine proteases, play a central role in apoptosis. During the last decade, major progress has been made to further understand caspase structure and function, providing a unique basis for drug design. This Review gives an overview of caspases and their classification, structure, and substrate specificity. We also describe the current knowledge of how interference with caspase signaling can be used to pharmacologically manipulate cell death.

PMID:
16200200
PMCID:
PMC1236692
DOI:
10.1172/JCI26252
[PubMed - indexed for MEDLINE]
Free PMC Article
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