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J Clin Invest. 2005 Oct;115(10):2648-55.

Pharmacological manipulation of Bcl-2 family members to control cell death.

Author information

1
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA. anthony_letai@dfci.harvard.edu

Abstract

The commitment to programmed cell death involves complex interactions among pro- and antiapoptotic members of the Bcl-2 family of proteins. The physiological result of a decision by these proteins to undergo cell death is permeabilization of the mitochondrial outer membrane. Pharmacologic manipulation of proteins in this family appears both feasible and efficacious, whether the goal is decreased cell death, as in ischemia of the myocardium or brain, or increased cell death, as in cancer.

PMID:
16200198
PMCID:
PMC1236690
DOI:
10.1172/JCI26250
[Indexed for MEDLINE]
Free PMC Article
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