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J Clin Invest. 2005 Oct;115(10):2640-7.

Mitochondria: pharmacological manipulation of cell death.

Author information

1
La Jolla Institute for Allergy and Immunology, Department of Cellular Immunology, San Diego, California 92121, USA.

Abstract

Cell death by apoptosis or necrosis is often important in the etiology and treatment of disease. Since mitochondria play important roles in cell death pathways, these organelles are potentially prime targets for therapeutic intervention. Here we discuss the mechanisms through which mitochondria participate in the cell death process and also survey some of the pharmacological approaches that target mitochondria in various ways.

PMID:
16200197
PMCID:
PMC1236694
DOI:
10.1172/JCI26274
[Indexed for MEDLINE]
Free PMC Article

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