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J Clin Invest. 2005 Oct;115(10):2610-7.

Pharmacological manipulation of cell death: clinical applications in sight?

Author information

1
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. douglas.green@stjude.org.or

Abstract

This series of Reviews on cell death explores the creation of new therapies for correcting excessive or deficient cell death in human disease. Signal transduction pathways controlling cell death and the molecular core machinery responsible for cellular self-destruction have been elucidated with unprecedented celerity during the last decade, leading to the design of novel strategies for blocking pathological cell loss or for killing unwanted cells. Thus, an increasing number of compounds targeting a diverse range of apoptosis-related molecules are being explored at the preclinical and clinical levels. Beyond the agents that are already FDA approved, a range of molecules targeting apoptosis-regulatory transcription factors, regulators of mitochondrial membrane permeabilization, and inhibitors or activators of cell death-related proteases are under close scrutiny for drug development.

PMID:
16200193
PMCID:
PMC1236695
DOI:
10.1172/JCI26321
[Indexed for MEDLINE]
Free PMC Article
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