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Neurol Res. 2005;27 Suppl 1:S29-35.

Endovascular neuroradiological treatment of acute ischemic stroke: techniques and results in 350 patients.

Author information

1
Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Inselspital, Switzerland.

Abstract

BACKGROUND AND OBJECTIVES:

Randomized trials have demonstrated the benefit of intra-arterial thrombolysis (IAT) for treatment of acute ischemic stroke, if performed within 6 hours of symptom onset.

METHODS:

We report our experience with 350 acute stroke patients who were treated with IAT using urokinase at a single center. Predictors of favorable outcome were low National Institute of Health Stroke Scale (NIHSS) at admission (p<0.001), good collaterals (p<0.001) and successful endovascular recanalization (p<0.001). Recanalization rates of more than 75% could be achieved, when additional endovascular techniques such as mechanical fragmentation of the thrombus, thromboaspiration, percutaneous transluminal angioplasty, and implantation of stents were used.

RESULTS AND CONCLUSIONS:

Predictors of unfavorable outcome were diabetes mellitus (p<0.001) and symptomatic hemorrhages (p<0.001). The latter occurred in 5% of our population. Preliminary results of new techniques including sonothrombolysis, angiojet aspiration, and laser recanalization of thromboembolic occlusions are discussed.

PMID:
16197821
DOI:
10.1179/016164105X35549
[Indexed for MEDLINE]

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