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Phys Rev Lett. 2005 Sep 9;95(11):118101. Epub 2005 Sep 7.

Intracellular transport of single-headed molecular motors KIF1A.

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Department of Aeronautics and Astronautics, Faculty of Engineering, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.


Motivated by experiments on single-headed kinesin KIF1A, we develop a model of intracellular transport by interacting molecular motors. It captures explicitly not only the effects of adenosine triphosphate hydrolysis, but also the ratchet mechanism which drives individual motors. Our model accounts for the experimentally observed single-molecule properties in the low-density limit and also predicts a phase diagram that shows the influence of hydrolysis and Langmuir kinetics on the collective spatiotemporal organization of the motors. Finally, we provide experimental evidence for the existence of domain walls in our in vitro experiment with fluorescently labeled KIF1A.

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