Format

Send to

Choose Destination
J Assist Reprod Genet. 2005 Aug;22(7-8):285-93.

Aneuploidy involving chromosome 1 in failed-fertilized human oocytes is unrelated to maternal age.

Author information

1
Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of California, San Francisco, USA. jlfung@itsa.ucsf.edu

Abstract

PURPOSE:

To study whether maternal meiotic errors in failed-fertilized oocytes involving chromosome 1 occur at frequencies similar to those involving other autosomes, and whether their frequency is affected by maternal age.

METHODS:

Using fluorescence in situ hybridization (FISH), frequencies of aneusomy and chromatid pre-division involving chromosomes 1, 16, 18, and 21 were determined for 273 failed-fertilized oocytes.

RESULTS:

The aneuploidy rate for chromosome 1 was 15.8%, and was neither age-dependent nor significantly different from that for chromosomes 16, 18 or 21. Only chromosome 16 exhibited an age-dependent increase in aneusomy rates. The frequency of chromatid pre-division was lower for chromosome 1 than for chromosome 18 (11.9% vs. 25.4%; p = 0.01), but not different from that for chromosomes 16 or 21.

CONCLUSION:

Aneuploidy involving chromosome 1 in failed-fertilized oocytes is unrelated to maternal age and occurs at a frequency similar to that for chromosomes 16, 18, and 21.

PMID:
16195825
DOI:
10.1007/s10815-005-5999-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center