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Neurol Sci. 2005 Oct;26(4):263-70.

Unilateral frontal lobe epilepsy affects executive functions in children.

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Developmental Neurology Division, Istituto Nazionale Neurologico C. Besta, Via Celoria 11, I-20133 Milan, Italy.


Very few studies to date have investigated the neuropsychological changes detectable in children suffering from frontal lobe epilepsy (FLE). The aim of the present study was to assess the effects of FLE on cognitive and executive functions in childhood. The sample includes 17 children with a frontal epileptogenic focus (10 right and 7 left), with no evidence of anatomical brain damage. These subjects were assessed by means of a battery of tests to investigate executive functioning. The results emphasised the presence of selective impairments of frontal lobe functions without evidence of deficits in global intellectual functioning. No side-specific deficits were detected, while an earlier onset of epilepsy and the duration of the disorder, but not the seizures frequency, were found to correspond with more severe deficits in some specific frontal lobe functions.

[Indexed for MEDLINE]

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