Format

Send to

Choose Destination
See comment in PubMed Commons below
J Am Acad Dermatol. 1992 Jul;27(1):34-7.

Failure of Borrelia burgdorferi to survive in the skin of patients with antibiotic-treated Lyme disease.

Author information

1
Department of Dermatology, State University of New York, Stony Brook.

Abstract

BACKGROUND:

Borrelia burgdorferi has been cultivated from clinically normal skin (previous erythema migrans sites) after antibiotic therapy for Lyme disease.

OBJECTIVE:

We investigated the possibility of similar findings in 13 of our patients with antibiotic-treated Lyme disease from whom B. burgdorferi was cultivated from their erythema migrans lesions before antibiotic therapy.

METHODS:

After treatment with doxycycline or a combination of amoxicillin and probenecid, skin biopsy specimens were obtained from clinically normal skin adjacent to the previous biopsy sites and cultured.

RESULTS:

B. burgdorferi was not cultivated from these posttreatment biopsy sites.

CONCLUSION:

The failure of B. burgdorferi to survive in the former erythema migrans sites of our antibiotic-treated patients, as well as their favorable clinical response, supports the use of doxycycline or combined amoxicillin and probenecid in the treatment of early Lyme disease but does not preclude the survival of the organism in other tissues.

PMID:
1619074
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center