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Opt Lett. 2005 Sep 1;30(17):2272-4.

In vivo brain imaging using a portable 3.9 gram two-photon fluorescence microendoscope.

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James H. Clark Center for Biomedical Engineering & Sciences, Stanford University, Stanford, California 94305-5435, USA.


We introduce a compact two-photon fluorescence microendoscope based on a compound gradient refractive index endoscope probe, a DC micromotor for remote adjustment of the image plane, and a flexible photonic bandgap fiber for near distortion-free delivery of ultrashort excitation pulses. The imaging head has a mass of only 3.9 g and provides micrometer-scale resolution. We used portable two-photon microendoscopy to visualize hippocampal blood vessels in the brains of live mice.

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