Format

Send to

Choose Destination
J Cell Physiol. 1992 Jul;152(1):185-9.

K-current mediation of prolactin-induced proliferation of malignant (Nb2) lymphocytes.

Author information

1
Division of Biomedical Sciences, University of California, Riverside 92521-0121.

Abstract

The effects of different concentrations of various K-current blockers on prolactin-induced proliferation and membrane K-currents in malignant lymphocytes (Nb2 cells) were investigated. Membrane currents were measured with the whole cell patch-clamp technique, and lymphocyte density was quantified by both spectrophotometric and conventional methods. K-current blockers tested (quinidine, 4-aminopyridine, barium, and tetraethylammonium) exhibited similar rank order potency for K-current block and inhibition of prolactin-induced proliferation of malignant lymphocytes. Because Nb2 cells proliferate independently of a transmembrane Ca-influx, these results suggest that K-currents per se rather than K-current modulation of Ca-influx is an essential event for lymphocyte proliferation.

PMID:
1618918
DOI:
10.1002/jcp.1041520123
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center