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Antimicrob Agents Chemother. 2005 Oct;49(10):4354-7.

parC mutations in fluoroquinolone-resistant Borrelia burgdorferi.

Author information

1
Division of Biological Sciences, The University of Montana, Missoula, 59812-4824, USA.

Abstract

We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.

PMID:
16189120
PMCID:
PMC1251557
DOI:
10.1128/AAC.49.10.4354-4357.2005
[Indexed for MEDLINE]
Free PMC Article

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